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Daniel W. Wesson, Ph.D.

Daniel Wesson, Ph.D.
Assistant Professor
Department of Neurosciences
Case Western Reserve University

School of Medicine
2109 Adelbert Ave
Cleveland OH, 44106-4975
Robbins bldg; room E643D (office) E643 (lab)

Phone : 216-368-6100
Email :
Website :


Neurocircuitry of olfactory perception and odor-guided behaviors

Dr. Wesson’s research interests lie at the interface of neuroscience and animal behavior. Experiments conducted in his laboratory combine in vivo electrophysiological recordings with precise cutting-edge behavioral methods to study central systems relevant to olfactory function. Ongoing studies include the contributions of the olfactory tubercle, a striatal structure with cortical-like organization, to olfaction and multi-sensory integration. We are also keenly working towards understanding the nature and utility of a previously undiscovered form of animal communication in rats which we recently uncovered – sniffing – to rat social behavior. Further, all of these major projects allow exciting opportunities to explore neural dysfunction in particular models of neurological disorders, including Alzheimer's disease. Together, these main projects bridge exciting ties between the sensory and cognitive neurosciences.

The techniques commonly used in these major questions include: 1) recordings of single neuron and local field potential activity from identified structures in animals performing odor-guided tasks, 2) neurochemical and genetic manipulations to alter function of identified neurons in the context of behavior, 3) wireless recordings of intra-nasal sniffing behavior from rats during social behaviors, and 4) neuroanatomical studies to explore novel pathways for the transmission of olfactory information throughout the brain.

Together these two unique lines of research compliment an understanding of information processing in the brain in a translational manner.



  1. Xia CZ, Adjei S, Wesson DW (2015)
    The coding of odor stimulus features in secondary olfactory structures. Journal of Neurophysiology. in press;
  2. Gadziola MA, Tylicki K, Christian D, Wesson DW (2015)
    The olfactory tubercle encodes odor valence in behaving mice. Journal of Neuroscience. 35:4515-27.
  3. Adjei S, Wesson DW (2015)
    Laminar and spatial localization of the islands of Calleja in mice Neuroscience. 287:137-43..
  4. Carlson KS, Dillione M, Wesson DW (2014)
    Odor- and state-dependent olfactory tubercle local field potential dynamics in awake rats. Journal of Neurophysiology.
  5. FitzGerald BJ, Richardson K, Wesson DW (2014)
    Olfactory tubercle stimulation alters odor preference behavior and recruits forebrain reward and motivational centers. Frontiers in Behavioral Neuroscience. 8
  6. Carlson KS, Xia CZ, Wesson DW (2013)
    Encoding and representation of intranasal CO2 in the mouse olfactory cortex. Journal of Neuroscience.
  7. Adjei S, Houck A, Ma K, Wesson DW (2013)
    Age-dependent alterations in the number, volume, and localization of islands of Calleja within the olfactory tubercle. Neurobiology of Aging. 34(11):2676-82.
  8. Wesson DW (2013)
    Sniffing behavior communicates social hierarchy. Current Biology. 23(7):575-580.
  9. Varga AG, Wesson DW (2013)
    Distributed auditory sensory input within the mouse olfactory cortex. European Journal of Neuroscience. 37(4):564-71.
  10. Wesson DW, Wilson DA (2011)
    Sniffing out the contributions of the olfactory tubercle to the sense of smell: hedonics, sensory integration, and more? Neurosci Biobehav Rev. 2011 Jan; 35(3):655-68.
faculty/wesson/index.txt · Last modified: 2015/05/18 14:53 by dww53