====== Robert Miller, Ph.D. ====== #template(faculty_profile.php|... * FName: Robert * LName: Miller * Degree: Ph.D. * Picture: miller-1.jpg * Position: Professor * Department: Department of Neurosciences * Organization: Case Western Reserve University * Address_1: School of Medicine, Room E653 * Address_2: 10900 Euclid Ave * Address_3: Cleveland OH, 44106-4975 * Phone: (216) 368-6269 * Fax: (216) 368-4650 * Email: rhm3@case.edu * PubMed_Search: Miller RH + Case Western )# ===== RESEARCH INTERESTS ===== The laboratory combines a primary interest in CNS neural development with a focus on understanding the biology of neural diseases including Multiple Sclerosis, Brain tumors and Cerebral Palsy. ==== Development ==== We are interested in understanding the cellular and molecular mechanisms that regulate glial cell determination in the developing vertebrate CNS. Oligodendrocytes, the myelinating cells of the CNS develop from precursors that arise in distinct locations within the embryonic neural tube. The origin of oligodendrocyte precursors is a result of local signaling including expression of sonic hedgehog. A number of other influences are required to develop the final pattern of oligodendrocyte in the mature tissue. These include dispersal signals to guide cell migration and stop signals such as the chemokine CXCL1 that position precursors to receive appropriate proliferative and differentiative cues. We are currently defining the interplay between these different signals in order to gain a complete understanding of oligodendrogenesis. ==== Disease ==== === Multiple Sclerosis === Precursor cells capable of giving rise to oligodendrocytes persist in the adult CNS and we are using a variety of approaches to determine whether these endogenous cells can be recruited to enhance repair of damaged white matter in the adult CNS. These include stimulation of cell proliferation and survival through delivery of specific proteins into focal lesions and the use of transgenic mice lacking critical components of the chemokine signal pathways. === Brain tumors === The majority of primary brain tumors are derived from glial lineage cells. Using information derived from out developmental studies we are determining whether distinct populations of brain tumors proliferate migrate and die in response to selected stimuli. === Cerebral Palsy === Cerebral Palsy is a commonly associated with insults to the developing CNS that result in aberrant development of myelinated regions. We are testing the hypothesis that the failure of normal development reflects a transient perturbation in the development of oligodendrocyte precursors. We have recently developed a novel model of fetal ischemia in rats and are using this model to develop interventional therapies to reduce the damage of prenatal insults. {{faculty:miller:olig-progression-final-copy.jpg?600}} (space) ===== SELECTED PUBLICATIONS ===== #template?key=Miller(dokudata.php|... * ID: 16563359 * Author: Miller RH. * Volume: * Issue: * Year: 2006 * Date: 2006 Mar 21 * Journal: Brain Res * Pages: * Title: The promise of stem cells for neural repair. * Selected: true ---- * ID: 16481423 * Author: Tsai HH, Macklin WB, Miller RH. * Volume: 26 * Issue: 7 * Year: 2006 * Date: 2006 Feb 15 * Journal: J Neurosci * Pages: 1913-1922 * Title: Netrin-1 is required for the normal development of spinal cord oligodendrocytes. * Selected: true ---- * ID: 16436890 * Author: Patzer JF 2nd, Safta SA, Miller RH. * Volume: 52 * Issue: 1 * Year: 2006 * Date: 2006 Jan-Feb * Journal: ASAIO J * Pages: 47-58 * Title: Slow continuous ultrafiltration with bound solute dialysis. * Selected: true ---- * ID: 16388796 * Author: Gao L, Macklin W, Gerson J, Miller RH. * Volume: 290 * Issue: 2 * Year: 2006 * Date: 2006 Feb 15 * Journal: Dev Biol * Pages: 277-286 * Title: Intrinsic and extrinsic inhibition of oligodendrocyte development by rat retina. * Status: 2006/01/04 [aheadofprint] * Selected: true ---- * ID: 16190599 * Author: Bambakidis NC, Theodore N, Nakaji P, Harvey A, Sonntag VK, Preul MC, Miller RH. * Volume: 19 * Issue: 3 * Year: 2005 * Date: 2005 Sep 15 * Journal: Neurosurg Focus * Pages: E1 * Title: Endogenous stem cell proliferation after central nervous system injury: alternative therapeutic options. * Selected: true ---- * ID: 16162555 * Author: Miller RH, West C, Brown TM, Sim I, Ganchoff C. * Volume: 24 * Issue: 5 * Year: 2005 * Date: 2005 Sep-Oct * Journal: Health Aff (Millwood) * Pages: 1127-1137 * Title: The value of electronic health records in solo or small group practices. Physicians' EHR adoption is slowed by a reimbursement system that rewards the volume of services more than it does their quality. * Selected: true ---- * ID: 16022332 * Author: Coleson JL, Miller RH. * Volume: 98 * Issue: 3 * Year: 2005 * Date: 2005 Jun * Journal: J Econ Entomol * Pages: 996-1006 * Title: Antibiosis and antixenosis to Aphis gossypii (Homoptera: Aphididac) in Colocasia esculenta. * Selected: true ---- * ID: 15958742 * Author: Sussman CR, Vartanian T, Miller RH. * Volume: 25 * Issue: 24 * Year: 2005 * Date: 2005 Jun 15 * Journal: J Neurosci * Pages: 5757-5762 * Title: The ErbB4 neuregulin receptor mediates suppression of oligodendrocyte maturation. * Selected: true ---- * ID: 15895088 * Author: Mi S, Miller RH, Lee X, Scott ML, Shulag-Morskaya S, Shao Z, Chang J, Thill G, Levesque M, Zhang M, Hession C, Sah D, Trapp B, He Z, Jung V, McCoy JM, Pepinsky RB. * Volume: 8 * Issue: 6 * Year: 2005 * Date: 2005 Jun * Journal: Nat Neurosci * Pages: 745-751 * Title: LINGO-1 negatively regulates myelination by oligodendrocytes. * Status: 2005/05/15 [aheadofprint] * Selected: true ---- * ID: 15755683 * Author: Robinson S, Petelenz K, Li Q, Cohen ML, Dechant A, Tabrizi N, Bucek M, Lust D, Miller RH. * Volume: 18 * Issue: 3 * Year: 2005 * Date: 2005 Apr * Journal: Neurobiol Dis * Pages: 568-581 * Title: Developmental changes induced by graded prenatal systemic hypoxic-ischemic insults in rats. * Selected: true ---- * ID: 15629694 * Author: Miller RH. * Volume: 45 * Issue: 1 * Year: 2005 * Date: 2005 Jan 6 * Journal: Neuron * Pages: 1-3 * Title: Dorsally derived oligodendrocytes come of age. * Selected: true ---- * ID: 15048926 * Author: Miller RH, Dinsio K, Wang R, Geertman R, Maier CE, Hall AK. * Volume: 76 * Issue: 1 * Year: 2004 * Date: 2004 Apr 1 * Journal: J Neurosci Res * Pages: 9-19 * Title: Patterning of spinal cord oligodendrocyte development by dorsally derived BMP4. * Selected: true ---- * ID: 15048925 * Author: Hall AK, Miller RH. * Volume: 76 * Issue: 1 * Year: 2004 * Date: 2004 Apr 1 * Journal: J Neurosci Res * Pages: 1-8 * Title: Emerging roles for bone morphogenetic proteins in central nervous system glial biology. ---- * ID: 14749190 * Author: Bambakidis NC, Miller RH. * Volume: 4 * Issue: 1 * Year: 2004 * Date: 2004 Jan-Feb * Journal: Spine J * Pages: 16-26 * Title: Transplantation of oligodendrocyte precursors and sonic hedgehog results in improved function and white matter sparing in the spinal cords of adult rats after contusion. * Selected: true ---- * ID: 12966218 * Author: Jacobsen CT, Miller RH. * Volume: 25 * Issue: 2-4 * Year: 2003 * Date: 2003 Mar-Aug * Journal: Dev Neurosci * Pages: 207-216 * Title: Control of astrocyte migration in the developing cerebral cortex. * Selected: true ---- * ID: 12859063 * Author: Bambakidis NC, Wang RZ, Franic L, Miller RH. * Volume: 99 * Issue: 1 Suppl * Year: 2003 * Date: 2003 Jul * Journal: J Neurosurg * Pages: 70-75 * Title: Sonic hedgehog-induced neural precursor proliferation after adult rodent spinal cord injury. * Selected: true ---- * ID: 12668624 * Author: Tsai HH, Tessier-Lavigne M, Miller RH. * Volume: 130 * Issue: 10 * Year: 2003 * Date: 2003 May * Journal: Development * Pages: 2095-2105 * Title: Netrin 1 mediates spinal cord oligodendrocyte precursor dispersal. * Selected: true ---- * ID: 12424732 * Author: Baracskay KL, Duchala CS, Miller RH, Macklin WB, Trapp BD. * Volume: 70 * Issue: 5 * Year: 2002 * Date: 2002 Dec 1 * Journal: J Neurosci Res * Pages: 645-654 * Title: Oligodendrogenesis is differentially regulated in gray and white matter of jimpy mice. * Selected: true ---- * ID: 12385864 * Author: Miller RH. * Volume: 67 * Issue: 6 * Year: 2002 * Date: 2002 Aug * Journal: Prog Neurobiol * Pages: 451-467 * Title: Regulation of oligodendrocyte development in the vertebrate CNS. * Selected: true ---- * ID: 12237843 * Author: Sussman CR, Davies JE, Miller RH. * Volume: 40 * Issue: 1 * Year: 2002 * Date: 2002 Oct * Journal: Glia * Pages: 55-64 * Title: Extracellular and intracellular regulation of oligodendrocyte development: roles of Sonic hedgehog and expression of E proteins. * Selected: true ---- * ID: 12176324 * Author: Tsai HH, Frost E, To V, Robinson S, Ffrench-Constant C, Geertman R, Ransohoff RM, Miller RH. * Volume: 110 * Issue: 3 * Year: 2002 * Date: 2002 Aug 9 * Journal: Cell * Pages: 373-383 * Title: The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. * Selected: true ---- * ID: 11998681 * Author: Tsai HH, Miller RH. * Volume: 25 * Issue: 4 * Year: 2002 * Date: 2002 Apr * Journal: Trends Neurosci * Pages: 173-5; discussion 175 * Title: Glial cell migration directed by axon guidance cues. * Selected: true ---- * ID: 11756753 * Author: Viehover A, Miller RH, Park SK, Fischbach G, Vartanian T. * Volume: 23 * Issue: 4-5 * Year: 2001 * Date: 2001 * Journal: Dev Neurosci * Pages: 377-386 * Title: Neuregulin: an oligodendrocyte growth factor absent in active multiple sclerosis lesions. * Selected: true ---- * ID: 11756751 * Author: Nakatsuji Y, Miller RH. * Volume: 23 * Issue: 4-5 * Year: 2001 * Date: 2001 * Journal: Dev Neurosci * Pages: 356-363 * Title: Control of oligodendrocyte precursor proliferation mediated by density-dependent cell cycle protein expression. * Selected: true ---- * ID: 11746367 * Author: Nakatsuji Y, Miller RH. * Volume: 66 * Issue: 3 * Year: 2001 * Date: 2001 Nov 1 * Journal: J Neurosci Res * Pages: 487-496 * Title: Density dependent modulation of cell cycle protein expression in astrocytes. * Selected: true ---- * ID: 11336511 * Author: Davies JE, Miller RH. * Volume: 233 * Issue: 2 * Year: 2001 * Date: 2001 May 15 * Journal: Dev Biol * Pages: 513-525 * Title: Local sonic hedgehog signaling regulates oligodendrocyte precursor appearance in multiple ventricular zone domains in the chick metencephalon. * Selected: true ---- * ID: 11322447 * Author: Robinson S, Cohen M, Prayson R, Ransohoff RM, Tabrizi N, Miller RH. * Volume: 48 * Issue: 4 * Year: 2001 * Date: 2001 Apr * Journal: Neurosurgery * Pages: 864-73; discussion 873 * Title: Constitutive expression of growth-related oncogene and its receptor in oligodendrogliomas. * Selected: true ---- * ID: 11259118 * Author: Noll EN, Lin J, Nakatsuji Y, Miller RH, Black PM. * Volume: 168 * Issue: 2 * Year: 2001 * Date: 2001 Apr * Journal: Exp Neurol * Pages: 300-309 * Title: GM3 as a novel growth regulator for human gliomas. * Selected: true ---- * ID: 11259117 * Author: Nakatsuji Y, Miller RH. * Volume: 168 * Issue: 2 * Year: 2001 * Date: 2001 Apr * Journal: Exp Neurol * Pages: 290-299 * Title: Selective cell-cycle arrest and induction of apoptosis in proliferating neural cells by ganglioside GM3. * Selected: true ---- * ID: 10729341 * Author: Wu Q, Miller RH, Ransohoff RM, Robinson S, Bu J, Nishiyama A. * Volume: 20 * Issue: 7 * Year: 2000 * Date: 2000 Apr 1 * Journal: J Neurosci * Pages: 2609-2617 * Title: Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. * Selected: true ---- * ID: 10679778 * Author: Sussman CR, Dyer KL, Marchionni M, Miller RH. * Volume: 59 * Issue: 3 * Year: 2000 * Date: 2000 Feb 1 * Journal: J Neurosci Res * Pages: 413-420 * Title: Local control of oligodendrocyte development in isolated dorsal mouse spinal cord. * Selected: true ---- * ID: 10593611 * Author: Miller RH, Hayes JE, Dyer KL, Sussman CR. * Volume: 17 * Issue: 8 * Year: 1999 * Date: 1999 Dec * Journal: Int J Dev Neurosci * Pages: 753-763 * Title: Mechanisms of oligodendrocyte commitment in the vertebrate CNS. * Selected: true ---- * ID: 10588885 * Author: Miller RH. * Volume: 216 * Issue: 1 * Year: 1999 * Date: 1999 Dec 1 * Journal: Dev Biol * Pages: 359-368 * Title: Contact with central nervous system myelin inhibits oligodendrocyte progenitor maturation. * Selected: true ---- * ID: 10491397 * Author: Ueda H, Levine JM, Miller RH, Trapp BD. * Volume: 146 * Issue: 6 * Year: 1999 * Date: 1999 Sep 20 * Journal: J Cell Biol * Pages: 1365-1374 * Title: Rat optic nerve oligodendrocytes develop in the absence of viable retinal ganglion cell axons. * Selected: true ---- * ID: 10226001 * Author: Orentas DM, Hayes JE, Dyer KL, Miller RH. * Volume: 126 * Issue: 11 * Year: 1999 * Date: 1999 Jun * Journal: Development * Pages: 2419-2429 * Title: Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors. * Selected: true ---- * ID: 10206471 * Author: Orentas DM, Miller RH. * Volume: 18 * Issue: 3 * Year: 1998 * Date: 1998 Dec * Journal: Mol Neurobiol * Pages: 247-259 * Title: Regulation of oligodendrocyte development. ---- * ID: 9852583 * Author: Robinson S, Tani M, Strieter RM, Ransohoff RM, Miller RH. * Volume: 18 * Issue: 24 * Year: 1998 * Date: 1998 Dec 15 * Journal: J Neurosci * Pages: 10457-10463 * Title: The chemokine growth-regulated oncogene-alpha promotes spinal cord oligodendrocyte precursor proliferation. ---- * ID: 9788275 * Author: Zhou L, Trapp BD, Miller RH. * Volume: 54 * Issue: 2 * Year: 1998 * Date: 1998 Oct 15 * Journal: J Neurosci Res * Pages: 158-168 * Title: Demyelination in the central nervous system mediated by an anti-oligodendrocyte antibody. ---- * ID: 9784063 * Author: Shimoda A, Sugata F, Chen HS, Miller RH, Purcell RH. * Volume: 56 * Issue: 1 * Year: 1998 * Date: 1998 Jul * Journal: Virus Res * Pages: 25-39 * Title: Evidence for a bidirectional promoter complex within the X gene of woodchuck hepatitis virus. )# #template?query=Selected&key=Miller(publications.php|...)# #template?key=MIller(dokudata.php|...)# ~~NOTOC~~