Principles of Neural Development

(NEUR 427)

Director

Heather Broihier (x4326, heather.broihier@case.edu)

Students

Name	email (@case.edu)

Overview

This course will discuss underlying principles and recent advances in developmental neurobiology. Major topics to be addressed include generation of neural stem cells and specification of distinct neural subtypes during development, axonal and dendritic guidance, and synaptogenesis. The course will be taught from original research papers and reviews, and class participation is required. Grading will consist of a midterm (40%), final exam (40%), and class participation and seminar critiques.

Pre-requisites

NEUR 402 or consent of the course director.

Schedule

As the semester progresses, the entries under “Papers” and “Notes” will become active links to assigned readings (as pdf’s), problem sets, and powerpoints from lectures and possibly also from student presentations.

NEUR 427 - 2006 Tentative Schedule
Date			Topic	Papers	Notes
08/28	MON	Broihier	Introduction and Overview. Early Development of the nervous system		Lec1
08/30	WED	Broihier	Role of proneurals in neuronal specification—AS-C	Hassan[2000] Pera[2003] Sens[2000]	Lec2
09/04	MON	Labor Day, no class
09/06	WED	Broihier	Asymmetric cell division—N pathway	ma_1998 nrn1847	Lec3
09/11	MON	Bai	Genetic techniques for analysis of vertebrate neural development	dymecki06 fishell05 dymecki05	Lec4
09/13	WED	O’Gorman	Anteroposterior patterning in the CNS and Hox genes	dasen03hoxmn dasen03_supl	Lec5
09/18	MON	Bai	Dorsoventral patterning in the CNS and Shh	wijgerde muller05	Lec6
09/20	WED	Gaiano	Notch in forebrain development	yoon.gaiano Mizutani Gaiano
09/21	THU	Nicholas Gaiano seminar—attendance required
09/25	MON	Broihier	Motorneuron specification	pfaff2003 limnli.pdf	Lec8
09/27	WED	Miller	Oligodendrocyte specification	natneuro_kessaris_waves pnas_rowitch_olig_gene
10/02	MON	Yom Kippur, no class
10/04	WED	Hall	Neural crest—formation and migration	bixby_2002 ledouarin
10/05	THU	John Dowling seminar—attendance required
10/09	MON	Miller	Neuronal migration in vertebrate development	deuel_2006 tsai_2005
10/11	WED	Landreth	Molecular biology of neurotrophin signaling	glebova kuruvilla zweifel	Lec12
10/16-18		Society for Neuroscience Meeting, no class
10/23	MON	Midterm Exam
10/25	WED	Hall	Vertebrate sensory neuron development	nrn812 runxlchen
10/30	MON	Broihier	Invertebrate sensory neuron development	komiyama jefferis_2006	Fly-Olfaction
11/01	WED	Hall	Neurotrophins and retrograde signaling in the PNS	delcroix_2003
11/02	THU	Oliver Hobert seminar—attendance required
11/06	MON	Landmesser	Axon guidance in the retinotectal system	Chilton[2006] Brown[2000] McLaughlin[2005]
11/08	WED	Broihier	Axon guidance at the midline	Dickson_rev Keleman[2005] Stein[2001]	Midline Lecture
11/13	MON	Broihier	Motor axon guidance	Fan[2003]	11-13-Lec
11/15	WED	Broihier	Dendritic guidance and tiling	Shirasaki[2006]	11-15-Presentation
11/20	MON	Landmesser	Synaptogenesis—cell-adhesion molecules and target specificity	Kavalali05 Washbourne Yamagata_03
11/22	WED	Thanksgiving Holiday, no class
11/27	MON	Silver	Axonal Regeneration	Silver-Regeneration
11/29	WED	Landmesser	Synaptogenesis—active zone assembly and differentiation	Tozuka05 Zhang_Poo_01
12/04	MON	Landmesser	Synaptogenesis—stability and activity	Ruthazer04 Pfeiffenberg05	Lecture Note
12/06	WED	Broihier	Dendritic guidance/tiling	Emoto[2006] Gallegos[2004]
12/11	MON	Final Exam